John Sheridan’s side sit in the final play-off spot – three points ahead of a chasing pack that includes Luton, Newport County and Exeter City.
With just three matches to go, a win in Cumbria this weekend, coupled with some favourable results elsewhere, could more or less book the Pilgrims a place in the end of season competition.
“By my estimation we need four points to get us in (the play-offs), so that’s a win and a draw from three games,” said Argyle’s performance manager John Harbin.
However, fourth-from-bottom Carlisle will be desperate for a win themselves. Three points for them at home could virtually secure their safety, with them having a six-point advantage over Cheltenham, who currently fill the second relegation spot.
Olly Lee could be struggling to make this weekend’s game after picking up a groin injury in Argyle’s draw with AFC Wimbledon on Tuesday.