Nelson missed Saturday’s 2-1 home win over Mansfield Town due to suspension.
That victory over The Stags moved John Sheridan’s side back into a promotion play-off position with just four matches of the season to go.
Argyle have a two point advantage over eighth-placed Newport County, but they need to make sure they make Tuesday’s match count as after Wimbledon’s visit the Greens will only have one more home fixture.
However, the Dons, who sit in 13th spot, will travel to Devon in confident mood, having won on their previous three visits to Home Park.
It is now make-or-break time for Argyle. Three wins from their final four games should be enough to secure a place in the play-offs.
The Greens have already played 47 matches this term but manager Sheridan does not think his players should be tired and will not use that as an excuse if they do not make the top seven.
“I feel the more games the better,” said Sheridan. “If I was a player I’d want to play in every game.”