The England international trio have just returned from competing on the Gold Coast but are happy to join their club colleagues for the prestigious meet in Cardiff.
Leander have an impressive record in the finals and have won the competition seven times in the last 10 years. They were runners-up last season.
They showed great form through qualifying and will have lane four on Sunday against defending champions Millfield, Stockport Metro, Guildford City, Hatfield, City of Oxford, Team Ipswich, Wycombe District Swimming Club, City of Peterborough and City of Derby.
They will be taking 50 athletes to Wales, with their youngest members being James Rostron, 10, and 11-year-old Blythe Kinsman.
Head coach Robin Armayan said: “It’s a great privilege for the Blue Army to make the National Arena League final again this year and compete against some of the best clubs in the country.
“It will be a fantastic opportunity for the swimmers to race as part of a team and represent PL to the best of their abilities.
“We expect a tough competition, packed with fast races and lots of fun!”
Plymouth Leander’s chairman David Ellis added: “The Arena League is the country’s major club competition and gives our athletes across the age groups the opportunity to test themselves against swimmers they wouldn’t ordinarily compete against.
“Obviously we’d like to return with the trophy again but, most importantly, we want our swimmers to enjoy the experience.”