Portsmouth have to play a National League Cup tie but as Cardiff were also without a game the teams have agreed to reschedule their National Southern Premier Division fixture.
Cardiff, whose team is bristling with internationals, did beat Argyle twice 3-2 last season and so they will know they will need to be at their best in Wales. But the Pilgrims go into the game in excellent form having won their last six games, scoring 33 goals and only conceding four.
“Having had the Portsmouth game cancelled I am more than delighted to be playing Cardiff,” said Argyle manager Dave Leonard.
“We know it’s going to be a tough game so I am really looking forward to it.
“This season has to be the most competitive season that I have seen. And we are playing our part in that. In fact it could come down to just two or three teams who could do it and if someone gets on a run who knows.”
He added: “We have a full squad to select from so it’s going to be a bit of a headache for me.
“Greek under-20 international Panagiota Papaioannou is still a couple of weeks away from contention but apart from that we go away with a fully fit squad.
“We go there confident in the way we have played in the last five weeks.
“We had a mega training session this week – not one of them moaned and they all worked hard. That to me empathises what these girls are all about, they are just relentless in their training.
“Not playing last Sunday they knew they were going to have a tough one this week, but their effort was relentless right through the session. It is just a different level to what it was last year but nobody is going to win anything in October, we just keep going to earn the three points.”
Leonard started with new recruits Bow Jackson and Lydia Huntley at the heart of the defence in their win at Buckland Athletic last time out but must decide whether to bring back captain Kate Middleton and Mollie into the starting line up.
Meanwhile, Argyle will start the defence of the Westward Development Devon Senior Cup with a quarter-final visit to Feniton on Sunday, November 17.
Argyle squad: Becky Kyle, Leah Burridge, Ebony Dover, Bow Jackson, Lydia Huntley, Faye Ivall, Jessica Jones, Amber Pollock, Kayley Lane, Becky Dandridge, Steph Beck, Zoe Cunningham, Natasha Knapman, Helen Bleazard, Kate Middleton, Mollie Taylor.
Argyle’s development team travel to unbeaten leaders Feniton on Sunday in the South West League Western Division knowing that a defeat might end their title challenge.
Feniton have won their four matches to date while the Argyle youngsters have won their last three matches in style after losing the opening three.
There will be a few changes to the squad as Scarlett Williams and Isla Brumhead are unavailable and there are a few players carrying niggling injuries. Back into squad come Rachel Heron and Rachel Javan.
The young Pilgrims travel to the game in a confident mood after three successive victories but knowing there is still a lot more to work on performance wise.
Manager Rob Bonney said: “It may seem that we are being hard on the girls, but despite the results recently, we know there is so much more that they can work on as a team. Sunday is another challenge that we will relish and are certainly looking forward to.”
Argyle development (from): Maddie Walsh, Jodie Randall, Rachel Heron, Rachel Javan, Maddy Leppard, Beth Cowd, Hannah Brock, Leah Johnson, Steph Beck, Beth Everson, Maisie Williams, Ellie Bishop, Lucy Solloway, Nicola Champion, Kiara Robins, Nelinha Barros.