England finished second behind 23-year-old Rebecca Guy in Sunday night’s final in a time of 25.62 seconds.
Her Leander team-mates Juliette Casini (26.23) and Anita M’Cartney (26.86) finished fourth and eighth respectively in the same final.
The last night of the Manchester meet was another successful one for Leander’s double Commonwealth Games champion Ben Proud.
Having won two golds on Saturday evening, Proud added a gold, silver and bronze medal on Sunday.
Proud won the 50m butterfly event, edging out Great Britain rival Adam Barrett. Proud clocked 23.21 seconds, with Loughborough’s Barrett touching in 23.50. Leander’s Kregor Kirk was eighth in 26.80. Kirk also took sixth in the 200m butterfly.
Proud took silver in the 100m freestyle in 49.01 seconds, before helping Leander to bronze in the 200m mixed medley relay alongside Eliza Duffy, Federico Poggio and Laura Stephens.
Duffy just missed out on a medal in the 50m backstroke, finishing fourth in 28.70 seconds, with team-mate Immie McCalman eighth in 30.00.
Poggio was fifth in the men’s 50m breaststroke in 29.14, while Stephens was sixth in the 100m butterfly in 1:02.31.
Other Leander finalists on the final day were Yael Danieli, who came sixth in the 800m freestyle (9:02.47) and fifth in the 400m IM (5:04.58); Tamir Gonen Cohen, who finished seventh in the 800m freestyle (9:06.83); Freddy Clampett, who was eighth in the 200m IM (2:08.75), and Tom Rudd (56.58), Ethan Harrington (56.86) and Frederick Cornwall (57.79) who came fifth, sixth and seventh respectively in the 100m backstroke.